The Effect of Sitagliptin and Exenatide on Insulin, Insulin Receptor and Insulin Receptor Substrate Gene Expression in Diabetic Rats

Yildirim M., Mistik O. A., Yalin A., Comelekoglu U., Berköz M., Arpaci R. B., ...More

Russian Journal of Bioorganic Chemistry, vol.49, no.3, pp.610-615, 2023 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 3
  • Publication Date: 2023
  • Doi Number: 10.1134/s1068162023030275
  • Journal Name: Russian Journal of Bioorganic Chemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core
  • Page Numbers: pp.610-615
  • Keywords: diabetes, exenatide, gene expression, insulin, sitagliptin
  • Van Yüzüncü Yıl University Affiliated: Yes


Abstract: Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia that results from abnormal secretion of insulin, inappropriate action of insulin or both. The aim of this study is to determine the effects of exenatide and sitagliptin treatment on the expression of insulin (INS-1), insulin receptor (INSR) and insulin receptor substrate (IRS-1) genes. In this study streptozotocin-induced diabetic rats were treated with sitagliptin (10 mg/kg) and exenatide (0.1 µg/kg) for 15 days. We measured INS-1, INSR and IRS-1 gene expression levels and examined the histology of pancreatic tissues in all groups. Exenatide and sitagliptin treatment increased gene expression levels of INS-1, INSR and IRS-1.