Is Nasal Polyposis Related to Levels of Serum Vitamin D and Vitamin D Receptor Gene Expression?

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ERDAG O., Turan M., Ucler R., Berköz M., Garca M. F., Bozan N., ...More

MEDICAL SCIENCE MONITOR, vol.22, pp.4636-4643, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22
  • Publication Date: 2016
  • Doi Number: 10.12659/msm.898410
  • Journal Name: MEDICAL SCIENCE MONITOR
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.4636-4643
  • Keywords: Calcifediol, Gene Expression, Nasal Polyps, D DEFICIENCY, CHRONIC RHINOSINUSITIS, RHEUMATOID-ARTHRITIS, ALLERGIC RHINITIS, CANCER PROGNOSIS, IMMUNE-SYSTEM, ASTHMA, POLYMORPHISMS, PROLIFERATION, FIBROBLASTS
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

Background: Nasal polyposis (NP) is the most frequent cause of nasal masses. Despite considerable research on the subject, its etiology has not been fully elucidated, and effective treatment methods have not been developed. Some etiological factors causing low or high expression of genes in genetically predisposed individuals may play a role in the pathogenesis of the disease. The purpose of this study was to assess the relation between levels of vitamin D receptor (VDR) gene expression and serum vitamin D with NP.