Saponins from Astragalus hareftae (NAB.) SIRJ

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Horo I., Bedir E., MASULLO M., PIACENTE S., Özgökçe F., Alankus-Caliskan O.

PHYTOCHEMISTRY, vol.84, pp.147-153, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 84
  • Publication Date: 2012
  • Doi Number: 10.1016/j.phytochem.2012.07.015
  • Journal Name: PHYTOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.147-153
  • Keywords: Astragalus, Saponin, Cycloartane, Oleanane, Hareftoside, CYCLOARTANE TRITERPENE GLYCOSIDES, CHEMICAL-CONSTITUENTS, MEMBRANACEUS BUNGE, ROOTS, SAPOGENOL, RADIX
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

A b s t r a c t
Four cycloartane- (hareftosides A–D) and oleanane-type triterpenoids (hareftoside E) were isolated from Astragalus hareftae along with fifteen known compounds. Structures of the compounds were established as 3,6-di-O-b-D-xylopyranosyl-3b,6a,16b,24(S),25-pentahydroxycycloartane (1), 3,6,24-tri-O-b-D-xylopyranosyl- 3b,6a,16b,24(S),25-pentahydroxycycloartane (2), 3-O-b-D-xylopyranosyl-3b,6a,16b,25-tetrahydroxy-
20(R),25(S)-epoxycycloartane (3), 16-O-b-D-glucopyranosyl-3b,6a,16b,25-tetrahydroxy-20(R), 24(S)-epoxycycloartane (4), 3-O-[b-D-xylopyranosyl-(1?2)-O-b-D-glucopyranosyl-(1?2)-O-b-D-glucuronopyranosyl]- soyasapogenol B (5) by the extensive use of 1D- and 2D-NMR experiments along with ESI-MS and HR-MS analyses.

Keywords: Astragalus, Saponin, Cycloartane, Oleanane, Hareftoside.

Four cycloartane- (hareftosides A-D) and oleanane-type triterpenoids (hareftoside E) were isolated from Astragalus hareftae along with fifteen known compounds. Structures of the compounds were established as 3,6-di-O-beta-D-xylopyranosyl-3 beta,6 alpha, 16 beta,24(S),25-pentahydroxycycloartane (1), 3,6,24-tri-O-beta-D-xylopyranosyl-3 beta,6 alpha,16 beta,24(S),25-pentahydroxycycloartane (2), 3-O-beta-D-xylopyranosyl-3 beta,6 alpha,16 beta,25-tetrahydroxy-20(R),25(S)-epoxycycloartane (3), 16-O-beta-D-glucopyranosyl-3 beta,6 alpha,16 beta,25-tetrahydroxy-20(R), 24(S)-epoxycycloartane (4), 3-O-[beta-D-xylopyranosyl-(1 -> 2)-O-beta-D-glucopyranosyl-(1 -> 2)-O-beta-D-glucuronopyranosyl]-soyasapogenol B (5) by the extensive use of 1D- and 2D-NMR experiments along with ESI-MS and HR-MS analyses. (c) 2012 Elsevier Ltd. All rights reserved.