The synergistic effects of testosterone and phophodiesterase-5 inhibitor combination on oxidative stress markers, matrix metalloproteinases and oxidative DNA damage: A randomized controlled experimental study

Aslan R., Taken K., Erbin A., Alp H. H., Eryılmaz R., Sarilar O., ...More

REVISTA INTERNACIONAL DE ANDROLOGIA, vol.20, no.2, pp.73-79, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.1016/j.androl.2020.10.011
  • Journal Name: REVISTA INTERNACIONAL DE ANDROLOGIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, DIALNET
  • Page Numbers: pp.73-79
  • Keywords: Tadalafil, Testosterone, Orchiectomy, Phosphodiesterase 5 inhibitors, CELLULAR PROCESSES, NADPH OXIDASE, EXPRESSION, PHOSPHODIESTERASE, REPLACEMENT, CASTRATION, ESTROGEN
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

Purpose: To investigate the effects of combined tadalafil and testosterone usage on oxidative stress, DNA damage and MMPs in testosterone deficiency.