The aim of this study was to investigate the changes in the blood serum concentration of some biochemical parameters and lipid-soluble vitamin levels in the goats naturaly infested with lice and Trichostrongylidae sp. before and after treatment with moxidectin and effects of moxidectin treatment on these blood parameters. In this study, 20 hair goats naturaly infected with lice (Linognathus africanus) and Trichostrongylidae sp. and 10 healthy hair goats (control) were used as material. Blood samples were collected from infested and control groups. Serum samples were seperated and analysed for biochemical parameters with autoanalyser and some vitamins with high performance liquid chromatography. Animals in infested group were treated with ecto-endoparasitic drug (moxidectin) and in 8 and 15 days after treatment blood samples were again collected to determine some vitamins and biochemical parameters. As a results, concentrations of retinol, sodium, potassium, calcium and albumin were lower (p<0.05) and activity of alanine aminotransferase was higher (p<0.05) in infected goats than in the controls. There was no statistically significant difference in the concentration of vit D-3, tocopherol, total protein, glucose and activity of aspartate aminotransferase and alkaline phosphatase between infected and control group.