Individual and simultaneous electroanalytical sensing of epinephrine and lidocaine using an anodically pretreated boron-doped diamond electrode by square-wave voltammetry


Talay Pınar P., Yardım Y., Şentürk Z.

DIAMOND AND RELATED MATERIALS, vol.101, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 101
  • Publication Date: 2020
  • Doi Number: 10.1016/j.diamond.2019.107649
  • Journal Name: DIAMOND AND RELATED MATERIALS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Chimica, Communication Abstracts, Compendex, INSPEC, Metadex, Civil Engineering Abstracts
  • Keywords: Lidocainc, Epinephrine, Determination, Boron-doped diamond electrode, Pharmaceutical dosage forms, WALLED CARBON NANOTUBES, ELECTROCHEMICAL DETERMINATION, CAPILLARY-ELECTROPHORESIS, URIC-ACID, SPECTROPHOTOMETRIC RESOLUTION, PHARMACEUTICAL-PREPARATIONS, SENSITIVE DETERMINATION, BIOGENIC-AMINES, ASCORBIC-ACID, MS/MS METHOD
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

In this study, the individual and simultaneous determination of lidocaine (LID) and epinephrine (EP) were examined using an anodically pretreated boron-doped diamond (APT-BDD) electrode. The results of cyclic voltammograms of the binary mixtures of EP and LID were manifested by two irreversible and diffusion-controlled peaks at about +0.91 V (for EP) and +1.67 V (for LID) in Britton-Robinson buffer at pH 2.0. The dependence of oxidation peak potential and current on experimental and instrumental parameters was also investigated at the surface of the APT-BDD electrode. Under the optimal conditions, employing square-wave voltammetric mode, the APT-BDD electrode was used for determination of LID and EP simultaneously in the ranges of 0.1-20.0 mu mol L-1 and 1.0-100.0 mu mol L-1, with detection limits of 0.03 mu mol L-1 and 0.27 mu mol L-1, respectively. The proposed approach could be used for their determination individually and selectively (in the case of EP) in pharmaceutical dosage forms with acceptable recoveries.