Individual and simultaneous electroanalytical sensing of epinephrine and lidocaine using an anodically pretreated boron-doped diamond electrode by square-wave voltammetry

Talay Pınar P. , Yardım Y. , Şentürk Z.

DIAMOND AND RELATED MATERIALS, cilt.101, 2020 (SCI İndekslerine Giren Dergi) identifier identifier


In this study, the individual and simultaneous determination of lidocaine (LID) and epinephrine (EP) were examined using an anodically pretreated boron-doped diamond (APT-BDD) electrode. The results of cyclic voltammograms of the binary mixtures of EP and LID were manifested by two irreversible and diffusion-controlled peaks at about +0.91 V (for EP) and +1.67 V (for LID) in Britton-Robinson buffer at pH 2.0. The dependence of oxidation peak potential and current on experimental and instrumental parameters was also investigated at the surface of the APT-BDD electrode. Under the optimal conditions, employing square-wave voltammetric mode, the APT-BDD electrode was used for determination of LID and EP simultaneously in the ranges of 0.1-20.0 mu mol L-1 and 1.0-100.0 mu mol L-1, with detection limits of 0.03 mu mol L-1 and 0.27 mu mol L-1, respectively. The proposed approach could be used for their determination individually and selectively (in the case of EP) in pharmaceutical dosage forms with acceptable recoveries.