Possible Role of GADD45 gamma Methylation in Diffuse Large B-Cell Lymphoma: Does It Affect the Progression and Tissue Involvement?


Baris I. C. , Caner V., Sen Turk N., Sari I., Hacioglu S., Dogu M. H. , ...More

TURKISH JOURNAL OF HEMATOLOGY, vol.32, no.4, pp.295-303, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.4274/tjh.2014.0174
  • Title of Journal : TURKISH JOURNAL OF HEMATOLOGY
  • Page Numbers: pp.295-303

Abstract

Objective: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma among adults and is characterized by heterogeneous clinical, immunophenotypic, and genetic features. Different mechanisms deregulating cell cycle and apoptosis play a role in the pathogenesis of DLBCL. Growth arrest DNA damage-inducible 45 (GADD45 gamma) is an important gene family involved in these mechanisms. The aims of this study are to determine the frequency of GADD45 gamma methylation, to evaluate the correlation between GADD45 gamma methylation and protein expression, and to investigate the relation between methylation status and clinicopathologic parameters in DLBCL tissues and reactive lymphoid node tissues from patients with reactive lymphoid hyperplasia.