First approach for the voltammetric sensing of rifabutin by the use of cationic surfactant media on the boron-doped diamond electrode

Barzani H. A., Yardım Y.

Diamond and Related Materials, vol.132, 2023 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 132
  • Publication Date: 2023
  • Doi Number: 10.1016/j.diamond.2022.109658
  • Journal Name: Diamond and Related Materials
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Chemical Abstracts Core, Communication Abstracts, INSPEC, Metadex, Civil Engineering Abstracts
  • Keywords: Boron-doped diamond electrode, Cationic surfactant, Pharmaceutical formulation, Rifabutin, Voltammetry
  • Van Yüzüncü Yıl University Affiliated: Yes


© 2022 Elsevier B.V.An excellent electrochemical sensor for determining rifabutin (RFB) by square-wave voltammetry was developed utilizing a non-modified boron-doped diamond electrode. Measurements of RFB using cyclic voltammetry with Britton-Robinson buffer (BR, 0.04 M, pH 7.0) solution revealed irreversible behaviour, diffusion-controlled as well as well-defined two oxidation peaks at around +0.67 (PA1) and + 1.23 (PA2) V vs Ag/AgCl. RFB oxidations depend critically on pH and supporting electrolytes. The anodic peak currents of the RFB were enormously enhanced by adding cetyltrimethylammonium bromide (CTAB, cationic surfactant) in the chosen supporting electrolyte, mainly when accumulating conditions were utilized. RFB was quantified using its two anodic peaks. By using optimized procedures also instrumental variables, the current response via RFB is proportionally linear throughout the concentration range of 0.1 to 10.0 μg mL−1 (1.18 × 10−7-1.18 × 10−5 M) via a detection limit of 0.030 μg mL−1 (3.54 × 10−8 M) for PA1 and 0.026 μg mL−1 (3.07 × 10−8 M) for PA2 in BR buffer (PH 7.0) solution. Ultimately, the proposed approach was accurately utilized to evaluate RFB in pharmaceutical formulation. To the greatest of our knowledge, this is the first approach for electroanalytical determination of RFB.