Synthesis of the 3,5-diphenyl-1H-pyrazole and cytogenetic and oxidative alterations after exposure of cultured human whole blood cells

Akbaş E., Celikezen F. C., Turkez H., Ozdemir O., Rüzgar A., Ergan E., ...More

COGENT CHEMISTRY, vol.3, no.1, 2017 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 3 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.1080/23312009.2017.1344115
  • Journal Name: COGENT CHEMISTRY
  • Journal Indexes: Emerging Sources Citation Index (ESCI)
  • Keywords: pyrazole, thiosemicarbazide, cytotoxic, INDUCED LIVER-INJURY, BIOLOGICAL EVALUATION, IN-VITRO, REGIOSELECTIVE SYNTHESIS, PYRAZOLE DERIVATIVES, AFLATOXIN B-1, SOLID-STATE, ANTICANCER, TOXICITY, AGENTS
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

The 3,5-diphenyl-1H-pyrazole was obtained by condensation reaction of dibenzoylmethane and thiosemicarbazide in acetic acid under conventional heating and microwave irradiation method. The structure of the 3,5-diphenyl-1H-pyrazole confirmed by IR, H-1, and C-13 NMR and X-ray diffraction and the geometry optimization was carried out using density functional theory (DFT) methods at B3LYP/6-31G, 6-31G(d), 6-31G(d, p), 6-311G(d, p), 6-311G(2d, 2p), 6-31+G(d, p), 6-311++G(d, p) levels. In addition, cytotoxic and oxidative effects were investigated in cultured human peripheral blood cells.