This study focuses on the average crustal and the upper mantle structure throughout the Lake Van region of eastern Turkey. The study aimed to investigate the structure with the fundamental mode interstation Rayleigh wave phase velocities from the local and the regional earthquakes recorded by Kandilli Observatory and Earthquake Research Institute stations. Considering back azimuth differences of each source and station path, six different broadband station pairs and 27 earthquakes were selected to determine the 1-D shear-wave velocity structures throughout the region by using an interstation method (slant stacking technique). The linearized least squares algorithm was used to obtain the 1-D shear-velocity model that best fit the observed phase velocity dispersion curve. The normalized statistical resolution matrix was calculated to measure the reliability of the solution. Inversion results revealed that the solution quality of the upper crust is weak due to the high resolution lengths. The average shear-wave velocities in the lower crust scale down to approximately 3.5 km/s. It was inferred that this low-velocity zone shown in the lower crust may be associated with widespread volcanism. Final 2-D S-wave velocity models obtained from the inversion revealed that the crust-mantle boundary is similar to 42 km, and shear velocities vary from 3.6 to 4.2 km/s. Furthermore, the upper mantle (similar to 45-70 km) velocities are slower than globally suggested models (e. g., IASP91), and this is possibly related to shallow hot asthenospheric material.