Aggressive Natural Killer Cell Leukemia: A Case Report and Literature Update

Ecirli S., Kutlu O., Andic N., Ugurluoglu C., Sakin A. , Basturk A.

ISTANBUL MEDICAL JOURNAL, cilt.16, ss.130-132, 2015 (ESCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 16 Konu: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.5152/imj.2015.09327
  • Sayfa Sayıları: ss.130-132


Aggressive natural killer cell leukemia (ANKL) is an extremely rare type of leukemia characterized by clonal NK cell infiltration of peripheral blood and the bone marrow, cytopenias, and hepato/splenomegaly. ANKL is an aggressive subtype of a large granular lymphocytic (LGL) leukemia. Peripheral blood smear shows LGL cells containing characteristic azurophilic granules in a light pale basophilic cytoplasm and immature nuclei. Immunological studies determine CD3-/CD16+/CD56+ and cytoplasmic CD3+. Tumor cells may have EBV positive. Chemotherapy resistance is caused by a multi-drug resistance gene (MDR); thus, patients die within 2 months after diagnosis. Here, we report a rare case of a patient diagnosed with ANKL.