The effect of thymoquinone on antioxidant vitamin levels in experimental diabetic rats


Usta A., Dede S., Yörük İ. H.

6th World Congress of Oxidative Stress, Calcium Signaling and TRP Channels (6.CMOS-2016), Isparta, Turkey, 24 - 27 May 2016, vol.8, no.1, pp.574-575

  • Publication Type: Conference Paper / Full Text
  • Volume: 8
  • City: Isparta
  • Country: Turkey
  • Page Numbers: pp.574-575
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

In this study, it were investigated that effects of thymoquinone (TQ) on antioxidant vitamin levels on experimental diabetic rats. Twenty-eight male WistarAlbino rats (200-250 g) were used as material. The rats were divided into four groups of control (C), thymoquinone (T), diabetes (D) and diabetes+thymoquinone (DT). D and DT groups were treated with 45 mg/kg streptozotocin (STZ) (i.p). TQ was administered as 30 mg/kg/21 day by oral gavage in DT and T groups. It was observed that the retinol concentrations significantly decreased in the diabetes and diabetes + TQ groups (p ≤ 0.05). There was no difference between the group delivered TQ and the control group. It was identified that the tocopherol concentrations were lower in all study groups than in the control group, and it was identified that the reduction in the diabetes and diabetes + TQ groups was significant when compared to the control group (p ≤ 0.05). It was identified that the vitamin D3 levels were significantly lower in the study groups when compared to the control group (p ≤ 0.05). It was identified that the serum antioxidant vitamin levels decreased in the group with experimental diabetes and that TQ administration did not significantly affect the antioxidant vitamin levels significantly in the group with experimental diabetes. Key words: experimental diabetes, antioxidant vitamins, thymoquinone