Akademik Veri Yönetim Sistemi
19th Euretina Congress, Paris, Fransa, 5 - 08 Eylül 2019, ss.62
Purpose:
To
investigate the effects of anti-glaucomatous drops (reduce humor aqueous production)
on clinical inflammation scores and
bacterial growth rates in Staphylococcus
aureus inoculated rabbit eyes.
Methods: Fifteen New Zealand rabbits were
used in the research. Left eyes (Group 1) of the rabbits selected as control (Placebo (Eyestil® hyaluronic
acid)) and the right eyes (Group 2) were
selected for research (Dorzolamide + Timolol (Cosopt® 20 mg/ml + 5
mg/ml). Eye drops were dropped into the eyes of each rabbit 12-hour intervals
twice. The S.aureus (3750 CFU/0.05
ml) ATCC 6538 strain was injected into
the anterior chamber of the right and left eyes two hours after the second
drops. Two independent and blind investigators scored the clinical inflammation in the subsequent 24.,48. and 72.
hours. Additionally, aqueous humor
samples that were obtained during the
follow-up were inoculated into pediatric
blood culture media for bacterial growth analysis.
Results: The
total score of inflammation was higher in Dorzolamide+Timolole applied eyes
comparing the controls. The significance rate was
reached on the first day (p=0,04).
The significance rate was lost in the following days, but still,
the inflammation was more severe in group 2. There was no statistically
significant difference in culture positivity between the groups on the first
and second days. There was a significant difference on the third day (p = 0.03)
Conclusions: Drugs that reduce humor aqueous production may
increase the risk of endophthalmitis in the postoperative period by reducing
aqueous humor clearance.