Auditory P300 event-related potentials in children with Sydenham's chorea

Ozdemir H. H. , Demiroren K., Demir C. F. , Serin M. H.

ARQUIVOS DE NEURO-PSIQUIATRIA, cilt.72, ss.603-608, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 72 Konu: 8
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1590/0004-282x20140099
  • Sayfa Sayıları: ss.603-608


P300 event-related potentials (ERPs), objective measures related to cognitive processing, have not been studied in Sydenham's chorea (SC) patients. Purpose: To assess cognitive impairment with P300 ERPs. Method: Seventeen patients with SC and 20 unaffected healthy children were included. Stanford-Binet test was used for psychometric assessment, and odd-ball paradigm was used for auditory ERPs. Results: There was no significant difference in P300 latencies between the SC-pretreatment group, SC-posttreatment group and control group (p>0.05). Mean interpeak latencies in SC-pretreatment group and SC-posttreatment group showed significant prolongation compared with the control group (p<0.05). Mean interpeak latencies in SC-posttreatment group were significantly decreased compared with SC-pretreatment group (p<0.05). Compared to controls, patients did not show significant difference in Stanford-Binet intelligence examination. Conclusion: This report suggests that interpeak latencies and amplitudes of P300 ERPs could be useful for detecting and monitoring cognitive impairment in SC patients.