Possible role of selective serotonin reuptake inhibitor sertraline on oxidative stress responses


Battal D., Yalin S., Eker E. D. , Aktas A., Sahin N. O. , Cebo M., ...More

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, vol.18, no.4, pp.477-484, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 4
  • Publication Date: 2014
  • Journal Name: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.477-484
  • Keywords: Sertraline, Oxidative stress, Antioxidant, Biomarker, TERM ANTIDEPRESSANT TREATMENT, MAJOR DEPRESSIVE DISORDER, LIPID-PEROXIDATION, FREE-RADICALS, SUPEROXIDE, ACID, NEUROTOXICITY, NEUROGENESIS, MODULATION, SYMPTOMS
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

The naphthylamine derivative sertraline is a potent and selective inhibitor of serotonin reuptake into presynaptic terminals and the most widely used that has been shown to have both antidepressant and antianxiety effects. In the present study the possible role of sertraline (acute and chronically doses) was evaluated on lipid peroxidation levels and antioxidant enzyme activities in plasma and brain tissues of (10, 40, 80 mg/kg) sertraline treated Wistar albino rats (n=48). Lipid peroxidation levels (MDA) of plasma and brain tissue increased in all acute and chronic sertraline treated rats (p < 0.05). According to results of present study superoxide dismutase (SOD) levels of brain tissue decreased while plasma levels increased (p < 0.05) as compared with vehicle group. Catalase (CAT) levels of plasma and brain tissue and paraoxonase (PON) levels of plasma decreased (p < 0.05) as compared with vehicle group. Based on the data, it can be concluded that high dose sertraline administration enhances oxidative stress. Therefore, dose adjustment in depression patients seems significant as it may help prevention of further prognosis of the diseases.