Saffron and Saffron Ingredients Like Safranal and Crocin’s Cytoprotective Effects on Carbon Tetrachloride Induced Liver Damage

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Aras İ., Bayram I., Oto G., Erten R., Almali A. Ö., Ilik Z. A.

Eastern Journal of Medicine, vol.27, no.3, pp.424-431, 2022 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 3
  • Publication Date: 2022
  • Doi Number: 10.5505/ejm.2022.34356
  • Journal Name: Eastern Journal of Medicine
  • Journal Indexes: Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.424-431
  • Keywords: Carbon tetrachloride, Crocin, Saffron, Safranal
  • Van Yüzüncü Yıl University Affiliated: Yes


© 2022, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.This study aims to investigate the liver-protective effects of saffron and saffron components like crocin and safranal against acute liver injury induced by carbon tetrachloride (CCI4) in rats. 72 male Wistar Albino rats were used in the study. The rats were divided into nine groups: 8 in each group. The rats were sacrificed at the end of the seventh day with high excretion (exsanguina tion). The protective effect of saffron, safranal, and crocin against CCI4-induced acute liver injury was evaluated histopathologically. In the study, balloon degeneration, apoptotic cells, and sub-massive necrosis were seen in hepatocytes as a result of-the effect of CCI4. These histopathological changes were hardly seen in groups in which CCI4 was administered with crocin and saffron. On the other hand, in the group where safranal and CCI4 were given together, changes similar to the histopathological changes seen in the CCI4 group were observed. It was concluded that crocin and saffron have a hepatoprotective effect in the experimental ac ute liver injury caused by CCI4, but the safranal has no protective effect on the liver.