The distinction of chiral compounds, which is one of the most popular topics of recent times, is actually of vital importance. This importance has caused the subject to be handled by many disciplines. Separation of enantiomers of chiral compounds was carried out using electrochemical methods within the scope of this study. Electrochemical sensor studies were carried out using carbon-based electrodes. As a result of the recent literature review, it has been determined that carbon material is frequently used in sensor studies. In this study, carbon material was synthesized as GO/β-CD derivative using chemical reduction method. SEM and XRD methods were used for the characterization of the synthesized catalyst. GO/SPCE and GO/β-CD/SPCE were produced by modifying the obtained carbon-based materials on the surface of surface-printed carbon electrodes. The activities of the electrochemical catalysts were characterized using the cyclic voltammetry (CV) method. Within the scope of this study, the enantioselectivity of ketoprofen, which is a chiral selective component, pain reliever and antipyretic drug substance, was determined by electrochemical methods.