Syndrome of inappropriate secretion of antidiuretic hormone cholestasis and pericardial effusion due to brucellosis infection: a case report


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Dülger A. C. , Kemik Ö. , Sümer A. , Akdeniz H. , Küçükoğlu M. E. , Canbaz E. T. , ...More

Case Report Med, pp.1-3, 2010 (Refereed Journals of Other Institutions)

  • Publication Type: Article / Article
  • Publication Date: 2010
  • Title of Journal : Case Report Med
  • Page Numbers: pp.1-3

Abstract

Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is an extremely rare complication of infectious diseases.
A rare case of brucellosis complicated by syndrome of inappropriate secretion of antidiuretic hormone (SIADH) cholestasis and
pericardial involvement is reported. A 27-year-old woman was admitted for fever, abdominal pain, and scleral icterus. Hermedical
history revealed no recent use of diuretic agents. In addition to cholestasis and elevated liver enzymes, euvolemic hyponatremia,
hypouricemia, low plasma osmolality, and high urinary osmolality were also detected. Surrenal and thyroid tests were also within
normal range. Echocardiography revealed minimal pericardial effusion with normal cardiac functions. The final diagnosis was
SIADH due to Brucellosis. Hyponatremia, cholestasis, and pericardial disease were resolved with effective antibrucellar treatment
with streptomycine and doxycycline. After completing treatment of brucellosis, there was not any more evidence of cholestasis and
pericardial fluid.