An unmodified boron-doped diamond electrode for electroanalytical investigation and sensitive voltammetric quantification of antiviral drug famciclovir in the pharmaceutical formulation and serum samples

Yardım Y., Ali H. S., Barzani H. A. H.

DIAMOND AND RELATED MATERIALS, vol.123, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 123
  • Publication Date: 2022
  • Doi Number: 10.1016/j.diamond.2022.108871
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Chemical Abstracts Core, Communication Abstracts, INSPEC, Metadex, Civil Engineering Abstracts
  • Keywords: Electrochemical determination, Square-wave voltammetry, Pretreatment, Drug analysis, HERPES-SIMPLEX-VIRUS, LC METHOD, PENCICLOVIR, VALIDATION, PHARMACOKINETICS, EFFICACY, MODE
  • Van Yüzüncü Yıl University Affiliated: Yes


The current study offers an electroanalytical investigation and a novel voltammetric approach for the quanti-tative analysis of famciclovir (FCV) utilizing an unmodified boron-doped diamond (BDD) electrode. An irre-versible, well-defined, diffusion-controlled anodic peak was observed at approximately +1.27 V (vs. Ag/AgCl) in acetate buffer solution (ABS, 0.1 mol L-1, pH 4.7) when the agent was tested using cyclic voltammetry. The voltammetric signals of the oxidation peaks are pH dependent (ranging from 2.0 to 7.0). Using square-wave mode, a good linear response was obtained for FCV quantification in 0.1 mol L-1 ABS (pH 4.7) solution at +1.26 V (vs. Ag/AgCl). Wide dynamic range was found for 0.1 to 50.0 mu g mL-1 (3.11 x 10-( 7)-1.56 x 10(-4) mol L-1), with a low detection limit of 0.029 mu g mL-1 (9.02 x 10(-8) mol L-1). Applicability of the proposed method for the determination of FCV was demonstrated in the pharmaceutical formulation and model serum samples.