An unmodified boron-doped diamond electrode for electroanalytical investigation and sensitive voltammetric quantification of antiviral drug famciclovir in the pharmaceutical formulation and serum samples
DIAMOND AND RELATED MATERIALS, cilt.123, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 123
- Basım Tarihi: 2022
- Doi Numarası: 10.1016/j.diamond.2022.108871
- Dergi Adı: DIAMOND AND RELATED MATERIALS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Chemical Abstracts Core, Communication Abstracts, INSPEC, Metadex, Civil Engineering Abstracts
- Anahtar Kelimeler: Electrochemical determination, Square-wave voltammetry, Pretreatment, Drug analysis, HERPES-SIMPLEX-VIRUS, LC METHOD, PENCICLOVIR, VALIDATION, PHARMACOKINETICS, EFFICACY, MODE
- Van Yüzüncü Yıl Üniversitesi Adresli: Evet
Özet
The current study offers an electroanalytical investigation and a novel voltammetric approach for the quanti-tative analysis of famciclovir (FCV) utilizing an unmodified boron-doped diamond (BDD) electrode. An irre-versible, well-defined, diffusion-controlled anodic peak was observed at approximately +1.27 V (vs. Ag/AgCl) in acetate buffer solution (ABS, 0.1 mol L-1, pH 4.7) when the agent was tested using cyclic voltammetry. The voltammetric signals of the oxidation peaks are pH dependent (ranging from 2.0 to 7.0). Using square-wave mode, a good linear response was obtained for FCV quantification in 0.1 mol L-1 ABS (pH 4.7) solution at +1.26 V (vs. Ag/AgCl). Wide dynamic range was found for 0.1 to 50.0 mu g mL-1 (3.11 x 10-( 7)-1.56 x 10(-4) mol L-1), with a low detection limit of 0.029 mu g mL-1 (9.02 x 10(-8) mol L-1). Applicability of the proposed method for the determination of FCV was demonstrated in the pharmaceutical formulation and model serum samples.