Synthesis, antibacterial and antifungal activity of some new pyridazinone metal complexes

SONMEZ M., BERBER İ., Akbas E.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.41, no.1, pp.101-105, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 41 Issue: 1
  • Publication Date: 2006
  • Doi Number: 10.1016/j.ejmech.2005.10.003
  • Journal Name: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.101-105
  • Keywords: pyridazinone complexes, antimicrobial activity, CU(II), CO(II), NI(II)
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

The new various metal complexes of 5-benzoyl-4-hydroxy-2-methyl-6-phenyl-2H-pyridazin-3-one were synthesized. All the complexes were evaluated for their antimicrobial activities against Gram-positive, Gram-negative bacteria and fungi using microdilution procedure. The Cd(II) and Ni(II) complexes exhibited selective and effective activities against one Gram-positive bacterium (Staplylococcus aureus ATCC 6538), one Gram-negative bacterium (Pseudonionas putida ATCC 12633) and against two yeast (Candida albicans ATCC 27541 and Candida tropicalis 1828) in contrast to poor activity observed other microorganisms. The new synthesized complexes were characterized using IR, H-1-NMR and UV spectral data together with elemental analysis. (c) 2005 Elsevier SAS. All rights reserved.