Oxidative Stress And Altered Levels of Oxidants And Antioxidants in Acute Ischemic Stroke Patients in A Region of East Turkey

Ozbey U., Seyran A., ERİŞİR M., Ozel S.

HEALTHMED, cilt.6, sa.5, ss.1574-1582, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 6 Sayı: 5
  • Basım Tarihi: 2012
  • Dergi Adı: HEALTHMED
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, Veterinary Science Database
  • Sayfa Sayıları: ss.1574-1582
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

Background and purpose: Ischemic stroke is one of the most important diseases causing severe disability and death. Hypertension is the most important risk factor in strokes, representing roughly 70% of all cases. Oxidative stress plays an important role in acute ischemic stroke (AIS) pathogenesis. It is believed to be one of the mechanisms taking part in neuronal damage in stroke. Free radical formation and subsequent oxidative damage may be a factor in stroke severity. In 28 patients with AIS and 28 healthy individuals were investigated with regard to relationship between ischemic-stroke and glutathione peroxidase (GSH-Px), catalase (CAT) activities, malondialdehyde (MDA), glutathione, beta-carotene, vitamin A levels.