Comparison of effects of high and low dose paracetamol treatment and toxicity on brain and liver in rats


Oksuz E. , Yaşar S. , Erten R. , Arihan O., Oto G.

NORTHERN CLINICS OF ISTANBUL, cilt.7, sa.6, ss.541-550, 2020 (ESCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 7 Konu: 6
  • Basım Tarihi: 2020
  • Doi Numarası: 10.14744/nci.2020.54926
  • Dergi Adı: NORTHERN CLINICS OF ISTANBUL
  • Sayfa Sayıları: ss.541-550

Özet

OBJECTIVE: Paracetamol is thought that it acts by inhibiting the central cyclooxygenase (COX) enzyme; its mechanism of action is still not fully explained. Although its most important side effect is hepatoxicity, it is thought to cause toxicity on the brain in recent years. The present study aims to investigate the treatment and toxic effects of low and high doses of paracetamol on the liver and brain.