Peripheral lymphocyte DNA damage and oxidative stress in patients with ulcerative colitis


Aslan M., Nazligul Y., Bolukbas C., Bolukbas F. F. , Horoz M., Dulger A. C. , ...More

POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ-POLISH ARCHIVES OF INTERNAL MEDICINE, vol.121, pp.223-229, 2011 (SCI-Expanded) identifier identifier identifier

Abstract

Introduction Ulcerative colitis (UC) is a fairly common chronic inflammatory disorder. Chronic inflammation may contribute to the risk of colorectal cancer through the accumulation of specific products resulting from DNA damage. Previous studies reported that DNA damage and oxidative stress play a significant role in the pathophysiology of UC, but the results are inconsistent.