Red cell distribution width, mean platelet volume, and vitamin B-12 levels in patients with schizophrenia: an observational study

ASOĞLU M., Aslan M. , Canbolat O., Imre O., Savik E., Kivrak Y., ...Daha Fazla

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, cilt.9, ss.16629-16636, 2016 (SCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 9 Konu: 8
  • Basım Tarihi: 2016
  • Sayfa Sayıları: ss.16629-16636


Objectives: Increasing evidence suggests an association between inflammation and schizophrenia. The aim of this study was to evaluate vitamin B-12, mean platelet volume (MPV) and red cell distribution width (RDW) levels in patients with schizophrenia. Materials and methods: Fifty-six patients diagnosed with schizophrenia and 30 age-and sex-matched controls were included in the study. Serum B-12, MPV and RDW levels were measured in all patients. Results: RDW levels were significantly higher in patients with schizophrenia than in the controls (P<0.001). MPV levels were increased in patients with schizophrenia; however, this increase was not statistically significant (P>0.05). Serum B-12 levels were significantly lower in patients with schizophrenia than controls (P<0.001). Conclusions: Our results demonstrated that schizophrenic patients had high RDW and MPV levels along with decreased B-12 levels. Increased inflammation may play a pathophysiological role in the development of atherosclerosis in schizophrenic patients.