Impact of glucocorticoid receptor gene (NR3C1) polymorphisms in Turkish patients with metabolic syndrome

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Kaya Z., Caglayan S., AKKİPRİK M., Aral C., Özışık G., Özata M., ...More

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, vol.39, no.5, pp.557-566, 2016 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 39 Issue: 5
• Publication Date: 2016
• Doi Number: 10.1007/s40618-015-0409-1
• Journal Name: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.557-566
• Van Yüzüncü Yıl University Affiliated: Yes

Abstract

Background The metabolic syndrome (MetS) is characterized by a cluster of metabolic factors, including insulin resistance and type-2 diabetes, abdominal obesity, dyslipidemia, hypertension and microalbuminuria. Impaired glucocorticoid receptor (GR) activity also plays an important role in the etiology of MetS. The objective of our study is to evaluate the effects of GR gene polymorphisms (BclI, N363S, TthIII1 and ER22/23EK) in Turkish patients with MetS.