Antinociceptive and anti-inflammatory activities of Viburnum lantana

Yilmaz B. S. , Citoglu G. S. , Altun M. L. , Ozbek H.

PHARMACEUTICAL BIOLOGY, cilt.45, sa.3, ss.241-245, 2007 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Konu: 3
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1080/13880200701213187
  • Sayfa Sayıları: ss.241-245


Water extract of Viburnum lantana L. ( Caprifoliaceae) ( VL) leaf was investigated for antinociceptive and anti-inflammatory activities in mice and rats. The tail-flick test, acetic acid-induced writhing test, and the carrageenan-induced rat paw edema test were used to determine these effects. Our findings show that VL causes dose-related inhibition in acetic acid-induced abdominal stretching in mice. VL inhibited abdominal stretching at 100 mg/kg, which is similar to that of aspirin, but this extract exhibited stronger antinociceptive activity than aspirin at a 200 mg/kg dose. VL showed powerful antinociceptive activity, which was quantified by a tail-flick test in 100 mg/kg dose. The anti-inflammatory activity of VL was not found to be significantly different at doses of 100 and 200 mg/kg. As a result, VL had shown slight anti-inflammatory activity compared with indomethacin. The LD50 of VL was determined as 2.169 g/kg.