Ursodeoxycholic acid induced generalized fixed drug eruption

Ozkol H. U., Calka O., Dulger A. C., Bulut G.

CUTANEOUS AND OCULAR TOXICOLOGY, vol.33, no.3, pp.256-258, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 3
  • Publication Date: 2014
  • Doi Number: 10.3109/15569527.2013.838253
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.256-258
  • Van Yüzüncü Yıl University Affiliated: Yes


Fixed drug eruption (FDE) is a rare form of drug allergies that recur at the same cutaneous or mucosal site in every usage of drug. Single or multiple round, sharply demarcated and dusky red plaques appear soon after drug exposure. Ursodeoxycholic acid (UDCA: 3 alpha,7 beta-dihydroxy-5 beta-cholanic acid) is used for the treatment of cholestatic liver diseases. Some side effects may be observed, such as diarrhea, dyspepsia, pruritus and headaches. We encountered only three cases of lichenoid reaction regarding the use of UDCA among previous studies. In this article, we reported a generalized FDE case related to UDCA intake in a 59-year-old male patient with cholestasis for the first time in the literature.