Ursodeoxycholic acid induced generalized fixed drug eruption


Ozkol H. U. , Calka O., Dulger A. C. , Bulut G.

CUTANEOUS AND OCULAR TOXICOLOGY, cilt.33, ss.256-258, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 33 Konu: 3
  • Basım Tarihi: 2014
  • Doi Numarası: 10.3109/15569527.2013.838253
  • Dergi Adı: CUTANEOUS AND OCULAR TOXICOLOGY
  • Sayfa Sayıları: ss.256-258

Özet

Fixed drug eruption (FDE) is a rare form of drug allergies that recur at the same cutaneous or mucosal site in every usage of drug. Single or multiple round, sharply demarcated and dusky red plaques appear soon after drug exposure. Ursodeoxycholic acid (UDCA: 3 alpha,7 beta-dihydroxy-5 beta-cholanic acid) is used for the treatment of cholestatic liver diseases. Some side effects may be observed, such as diarrhea, dyspepsia, pruritus and headaches. We encountered only three cases of lichenoid reaction regarding the use of UDCA among previous studies. In this article, we reported a generalized FDE case related to UDCA intake in a 59-year-old male patient with cholestasis for the first time in the literature.