The number and activity of CD3(+)TCR V alpha 7.2(+)CD161(+) cells are increased in children with acute rheumatic fever

ÖZKAYA M., BAYKAN A., Cakir M., VURAL Ç., Sunkak S., Unal E., ...More

INTERNATIONAL JOURNAL OF CARDIOLOGY, vol.333, pp.174-183, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 333
  • Publication Date: 2021
  • Doi Number: 10.1016/j.ijcard.2021.02.020
  • Journal Name: INTERNATIONAL JOURNAL OF CARDIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Public Affairs Index, Veterinary Science Database
  • Page Numbers: pp.174-183
  • Keywords: Acute rheumatic fever, ARF, Mucosal-associated invariant cell, MAIT, INVARIANT T-CELLS, HEART-DISEASE, MAIT CELLS, CYTOKINES, AUTOIMMUNITY, PATHOGENESIS, PROGRESSION, STATEMENT, CLONES, IL-17
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

Background: Acute rheumatic fever (ARF) is an autoimmune disease caused by group A beta-hemolytic streptococci (GAS) and may develop into rheumatic heart disease (RHD). The pathogenesis of ARF and RHD involves molecular mimicry and antibody-mediated mechanisms. T cell involvement is described in various stages of the disease. Mucosal associated invariant T (MATT) cells are enriched at the mucosa and are present in the blood and may be activated by GAS.