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ÖZKAYA M., BAYKAN A., Cakir M., VURAL Ç., Sunkak S., Unal E., ...More
INTERNATIONAL JOURNAL OF CARDIOLOGY, vol.333, pp.174-183, 2021 (SCI-Expanded)
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Publication Type:
Article / Article
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Volume:
333
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Publication Date:
2021
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Doi Number:
10.1016/j.ijcard.2021.02.020
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Journal Name:
INTERNATIONAL JOURNAL OF CARDIOLOGY
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Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Public Affairs Index, Veterinary Science Database
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Page Numbers:
pp.174-183
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Keywords:
Acute rheumatic fever, ARF, Mucosal-associated invariant cell, MAIT, INVARIANT T-CELLS, HEART-DISEASE, MAIT CELLS, CYTOKINES, AUTOIMMUNITY, PATHOGENESIS, PROGRESSION, STATEMENT, CLONES, IL-17
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Van Yüzüncü Yıl University Affiliated:
Yes
Abstract
Background: Acute rheumatic fever (ARF) is an autoimmune disease caused by group A beta-hemolytic streptococci (GAS) and may develop into rheumatic heart disease (RHD). The pathogenesis of ARF and RHD involves molecular mimicry and antibody-mediated mechanisms. T cell involvement is described in various stages of the disease. Mucosal associated invariant T (MATT) cells are enriched at the mucosa and are present in the blood and may be activated by GAS.