The number and activity of CD3(+)TCR V alpha 7.2(+)CD161(+) cells are increased in children with acute rheumatic fever
INTERNATIONAL JOURNAL OF CARDIOLOGY, cilt.333, ss.174-183, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 333
- Basım Tarihi: 2021
- Doi Numarası: 10.1016/j.ijcard.2021.02.020
- Dergi Adı: INTERNATIONAL JOURNAL OF CARDIOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Public Affairs Index, Veterinary Science Database
- Sayfa Sayıları: ss.174-183
- Anahtar Kelimeler: Acute rheumatic fever, ARF, Mucosal-associated invariant cell, MAIT, INVARIANT T-CELLS, HEART-DISEASE, MAIT CELLS, CYTOKINES, AUTOIMMUNITY, PATHOGENESIS, PROGRESSION, STATEMENT, CLONES, IL-17
- Van Yüzüncü Yıl Üniversitesi Adresli: Evet
Özet
Background: Acute rheumatic fever (ARF) is an autoimmune disease caused by group A beta-hemolytic streptococci (GAS) and may develop into rheumatic heart disease (RHD). The pathogenesis of ARF and RHD involves molecular mimicry and antibody-mediated mechanisms. T cell involvement is described in various stages of the disease. Mucosal associated invariant T (MATT) cells are enriched at the mucosa and are present in the blood and may be activated by GAS.