Decreased Prolidase Activity in Patients with Posttraumatic Stress Disorder

Demir S., BULUT M., ATLİ A., KAPLAN İ., KAYA M. C., Bez Y., ...More

PSYCHIATRY INVESTIGATION, vol.13, no.4, pp.420-426, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.4306/pi.2016.13.4.420
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Page Numbers: pp.420-426
  • Van Yüzüncü Yıl University Affiliated: Yes


Objective Many neurochemical systems have been implicated in the development of Posttraumatic Stress Disorder (PTSD). The prolidase enzyme is a cytosolic exopeptidase that detaches proline or hydroxyproline from the carboxyl terminal position of dipeptides. Prolidase has important biological effects, and to date, its role in the etiology of PTSD has not been studied. In the present study, we aimed to evaluate prolidase activity in patients with PTSD.