Aim: In order to determine the clinical and etiological characteristics of primer cutaneous vasculitis and to evaluate its relation with immunological mechanisms, Material and Method: Twenty-eight hospitalized patients with cutaneous vasculitis between 2009-2011 in dermatology service were investigated retrospectively. Patients' age, gender, disease duration, associated symptoms, infection, and drug history were recorded. Results of immune fluorescence biopsy and all laboratory tests including detailed antibodies which were investigated for the differential diagnosis of vasculitis were given in percent (%) after recording to SPSS 13.0 statistical software. Results: Median age of the 28 patients (18 female, 10 male) was 37,89-v23,30 (5-84 age) years. 39.3% patients had neutrophilia, 67.9% patients had eosinophilia. Antinuclear antibodies (ANA) in 10 patients (35.746) were positive. Total IgE in 15 patients (53.6%), IgA in 9 patients (32.1%), IgG in ID patients (.35.7%) was higher than normal range. Thyroglobulin in 3 patients (10.746), antiTPO 4 patients (14.3%),antirubella IgG in 14 patients (50.0%) antitoxoplazma IgG in 10 patients (35.7%) were positive. Anticardiolipin antibodies, anti-ssa 1 and Anti-ssb2, only one patient (3.66/u) was positive. Discussion: lmmunoglobulins and ANA were determined positively in a high ratio in patients with cutaneous leucocytoclastic vasculitis however there was no systemic involvement, Autoimmunity may have an important role in pathogenesis. Moreover drugs were most frequently determined among etiological factors.