6-methylthiouracil and 6-methyluracil derivatives synthesized by reaction of acetylketene with thiourea and urea compounds in presence of Yb(TFA)3

Aslanoğlu F., Yazıcı A.

Synthetic Communications, vol.53, no.20, pp.1713-1721, 2023 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 20
  • Publication Date: 2023
  • Doi Number: 10.1080/00397911.2023.2245506
  • Journal Name: Synthetic Communications
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica
  • Page Numbers: pp.1713-1721
  • Keywords: 2, 2, 3-dioxin-4-one, 6-methylthiouracil, 6-methyluracil, 6-trimethyl-4H-1, Yb(TFA)3
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

Thiouracil and uracil derivatives are among the bioactive molecules used in the treatment of many diseases, such as 6-propylthiouracil and 5-fluorouracil. A new synthesis method of 6-methylthiouracil and 6-methyluracil was developed in this study. Various 6-methylthiouracil and 6-methyluracil derivatives were obtained by reacting 2,2,6-trimethyl-4H-1,3-dioxin-4-one with thiourea and urea compounds in the presence of Yb(TFA)3 according to this new method. Optimization of this new method was performed. The structures of 6-methylthiouracil and 6-methyluracil derivatives were characterized.