Akademik Veri Yönetim Sistemi
JOURNAL OF PHARMACEUTICAL NEGATIVE RESULTS, cilt.13, sa.3, ss.796-803, 2022 (ESCI)
This work; It is aimed to adapt the Effect of Chromium Mineral Supplement on Serum Irisin, Leptin and Ghrelin Hormone Levels to Exercise
Trainings. For this purpose; A total of 28 male rats of eight weeks old Wistar Albino were included in the study and randomly divided into
four groups. The control group (n=7) who continued to be fed with a daily diet and waited for eight weeks without any supplementation;
The exercise group in which the treadmill exercise was performed at a speed of 15 m/min on the treadmill for five days for eight weeks
(n=7); supplementation group (n=7) given chromium picolinate by gavage method (8 µg / kg/day) once a day for eight weeks in addition to
daily dietary nutrition; In addition to dietary nutrition, a single dose (8 µg/kg/day) chromium picolinate was given by gavage for eight weeks
and supplemented + exercise group (n=7) in which 20 min/day treadmill exercise was performed for eight weeks. At the end of the studies,
which lasted for a total of 10 weeks with two weeks of adaptation exercises, blood samples were taken with the decapitations of the rats.
Irisin, leptin and ghrelin analyzes in blood samples were studied by preparing them according to the kit procedure with the elisa method.
According to the data we obtained, the normality homogeneity test was applied and it was determined that the data were normally distributed.
As a result, one way anova test and paired sample t test were applied from parametric tests (p<0.05 statistically significant difference was
accepted) and tukey test was applied to determine the difference between groups. SPSS-21 package program was used in the analysis of the
data (p< 0.05 was considered a statistically significant difference). Correlation test was used to determine the relationship between variables.
As a result, treadmill exercise applied at a speed of 20 minutes, 15 km/h, 5 days a week for eight weeks, and chromium mineral
supplementation decreased the hormone level of ghrelin, thus reducing the need for food intake and less energy consumption. It was found
that the use of chromium picolinate alone had a lowering effect on the leptin hormone, and that it also reduced the leptin hormone level in
long-term exercise, that the combination of chromium picolinate supplement and exercise further reduced the already low leptin level
compared to the chromium group and exercise group. We found that the level was significantly reduced