NF-kappa B-Induced Upregulation of miR-548as-3p Increases Invasion of NSCLC by Targeting PTEN


Akgun S., Kucuksayan H., Ozes O. N. , Can Ö. , Alikanoglu A. S. , Yildiz M., ...More

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, vol.19, no.8, pp.1058-1068, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 8
  • Publication Date: 2019
  • Doi Number: 10.2174/1871520619666190206165215
  • Title of Journal : ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
  • Page Numbers: pp.1058-1068

Abstract

Background: Non-Small Cell Lung Cancer (NSCLC) is an aggressive cancer type due to high metastatic capacity. Nuclear Factor Kappa B (NF-kappa B) is a consistently active transcription factor in malignant lung cancer cells and has crucial significance in NSCLC progression. It is also implicated in the transcriptional regulation of many genes including microRNAs (miRNAs) that function as tumor suppressor or oncogene. It has been increasingly reported that several miRNAs defined as gene members are induced by NF-kappa B. The present study aimed to find novel miRNAs that are regulated by NF-kappa B.