NF-kappa B-Induced Upregulation of miR-548as-3p Increases Invasion of NSCLC by Targeting PTEN

Akgun, Sakir; Kucuksayan, Hakan; Ozes, Osman; Can, Özge; Alikanoglu, Arsenal; Yildiz, Mustafa; Akca, Hakan

doi:10.2174/1871520619666190206165215

NF-kappa B-Induced Upregulation of miR-548as-3p Increases Invasion of NSCLC by Targeting PTEN

Akgun S., Kucuksayan H., Ozes O. N., Can Ö., Alikanoglu A. S., Yildiz M., ...Daha Fazla

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, cilt.19, sa.8, ss.1058-1068, 2019 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 19 Sayı: 8
Basım Tarihi: 2019
Doi Numarası: 10.2174/1871520619666190206165215
Dergi Adı: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1058-1068
Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

Background: Non-Small Cell Lung Cancer (NSCLC) is an aggressive cancer type due to high metastatic capacity. Nuclear Factor Kappa B (NF-kappa B) is a consistently active transcription factor in malignant lung cancer cells and has crucial significance in NSCLC progression. It is also implicated in the transcriptional regulation of many genes including microRNAs (miRNAs) that function as tumor suppressor or oncogene. It has been increasingly reported that several miRNAs defined as gene members are induced by NF-kappa B. The present study aimed to find novel miRNAs that are regulated by NF-kappa B.