Our Radiotherapy Results in Patients with Primary Non-Small Cell Lung Cancer with Brain Metastases


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Karaca F., Menteş S., Arslan A., Saraç M. E., Keskin S., Çil T.

KSÜ Tıp Fakültesi Dergisi, vol.18, no.1, pp.1-8, 2023 (Peer-Reviewed Journal)

  • Publication Type: Article / Article
  • Volume: 18 Issue: 1
  • Publication Date: 2023
  • Journal Name: KSÜ Tıp Fakültesi Dergisi
  • Journal Indexes: TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1-8
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

Abstract

Objective: Lung cancer is the most common cancer worldwide and is among the leading causes of cancer death. The aim of this study is to examine the survival of patients who received radiotherapy for the brain metastases, whose primary is non-small cell lung cancer, and also determine the factors that are like to affect the survival and to examine the results of radiotherapy in these patients as well.

Materials and Methods: This study included 99 patients with primary non-small cell lung cancer. All patients with brain metastases received radiotherapy. The patients were grouped and compared according to the number of brain metastases, whether surgery was performed for brain metastasis, gender, pathology and stage of the primary focus, visceral organ involvement, and ECOG performance status after brain metastasis developed.

Results: The change in survival rate according to the number of brain metastases at the time of diagnosis was found statistically significant (p<0.01). When the stages and survival of the patients at the time of diagnosis were compared, it was statistically significant (p<0.01). Similarly, the differences among the ECOG/PS status was also statistically significant (p<0.01). When patients with visceral organ metastases were divided into two groups as to groups as dead and alive, it was observed that the number of exitus that most of the patients were lost to their metastatic state (p<0.001).

Conclusion: Age, gender, the number of brain metastases the number of brain metastases brain metastasis, surgery, ECOG/PS, chemotherapy, radiotherapy and visceral organ metastasis were found to be factors affecting survival in patients with brain metastases.