In Vitro Enzyme Inhibitory Activity of Ten Ferulago W. Koch Species Growing in Turkey


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AKKOL E., GÜNBATAN T., GÜRBÜZ İ., DUMAN H., KILIÇ C. S., İlhan M.

BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY, vol.65, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 65
  • Publication Date: 2022
  • Doi Number: 10.1590/1678-4324-2022210207
  • Journal Name: BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Animal Behavior Abstracts, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Veterinary Science Database, Directory of Open Access Journals
  • Keywords: Ferulago, Collagenase, Elastase, Hyaluronidase, Wound, HUMAN NEUTROPHIL ELASTASE, ESSENTIAL OIL COMPOSITION, CHEMICAL-COMPOSITION, ANTIMICROBIAL ACTIVITIES, MEDICINAL-PLANTS, MATRIX METALLOPROTEINASES, ISAURICA PESMEN, SYRIACA BOISS., AERIAL PARTS, WOUND REPAIR
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

Ferulago species are traditionally used for the treatment of skin diseases, bronchitis, and depression, to increase body strength, as an immunostimulant, aphrodisiac and sedative in Anatolia. In this study, hyaluronidase, collagenase and elastase inhibitory potential relevant to wound healing activities of ethanol extracts from the roots of ten Ferulago species [F. cassia Boiss., F. humilis Boiss., F. isaurica Pesmen, F. longistylis Boiss., F. mascrosciadia Boiss. & Balansa, F. sandrasica Pesmen & Quezel, F. setifolia K. Koch., F. silaifolia (Boiss.) Boiss., F. trojana Akalin & Pimenov formerly known as F. sylvatica (Besser) Rchb. and F. syriaca Boiss.] were investigated. Ethanol extracts of F. mascrosciadia and F. syriaca were the most active ones against collagenase and elastase, respectively. In vitro wound healing activity of ten Ferulago species is reported for the first time in the current study.