Design of 1-(2-pyrrolidinone)-butane-1,3-dione derivatives and acetoxylation of these compound's methylene via hypervalent iodine (III)

Aslanoğlu F.

JOURNAL OF HETEROCYCLIC CHEMISTRY, vol.59, no.9, pp.1660-1663, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 59 Issue: 9
  • Publication Date: 2022
  • Doi Number: 10.1002/jhet.4482
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), Chimica, EMBASE
  • Page Numbers: pp.1660-1663
  • Van Yüzüncü Yıl University Affiliated: Yes


An interesting synthesis method for 2-acetate-1-(2-pyrrolidinone)-butane-1,3-dione compounds was developed in this work. The synthesis of these compounds was carried out in three steps. In the first step, 2-pyrrolidone derivatives were obtained by the Friedel-Crafts reaction in presence of Eaton's reagent. Then, -NH group of 2-pyrrolidone compounds were attached acetoacetate group in presence of 2,6-trimethyl-4H-1,3-dioxin-4-one reagent. Lastly, 1-(2-pyrrolidinone)-butane-1,3-dione derivatives were reacted with Pida to attach acetoxy group to these compound's methylene.