The incorrect use of insecticides in many countries' vineyards may result in some toxicological risks for the consumers by their presence on the grapes. In this research, a rapid gas chromatographic method was used for the determination of the residue levels of two organophosphorus pesticides (chlorpyrifos and chlorpyrifos-methyl) in wine. Pesticides are described and compared with each other. Ten red wines from two different regions of Turkey were analyzed for their chlorpyrifos and chlorpyrifos-methyl content. The samples were diluted with water and extracted by solid-phase micro extraction. Nitrogen-Phosphorus Detection (NDP) and Electron-Capture Detection (ECD) were used to identify and quantify the pesticides, the findings being confirmed using Mass Spectrometric Detection. Individual detection limits were in the range of (chlorpyrifos) 0.02-(chlorpyrifos-methyl) 0.1 ng. Limits of quantification varied from (chlorpyrifos) 0.01-(chlorpyrifos-methyl) 0.05 mg kg(-1). The maximum residues limits of the two pesticides in the Turkish wines examined were much lower than the Turkish and European Union limits.