A subvulvar leiomyosarcoma in a Simmental cow-a case report

UYAR A., Düz E., Keleş Ö. F. , Yaman T., Yener Z.

VETERINARSKI ARHIV, vol.92, no.2, pp.213-221, 2022 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 92 Issue: 2
  • Publication Date: 2022
  • Doi Number: 10.24099/vet.arhiv.1406
  • Journal Indexes: Science Citation Index Expanded, Scopus, BIOSIS, CAB Abstracts, EMBASE, Veterinary Science Database
  • Page Numbers: pp.213-221
  • Keywords: surgery, histopathology, ?-SMA, vimentin, desmin, Ki67, perineal subvulvar leiomyosarcoma, Simmental cow, VAGINAL LEIOMYOSARCOMA, BREAST-CANCER, VIMENTIN, DESMIN, ACTIN


In this case, a mass located subcutaneously in the perineal subvulvar region of a six-year-old Simmental cow was examined clinically, pathomorphologically and immunohistochemically. Macroscopically, the solitary, whitish yellow-tumor mass was 19x15x6 cm in size, weighed 1610 grams, and had a lobular structure with a few small cystic formations in the section. Histopathological examination revealed that the tumor parenchyma had smooth muscle-like cells with abundant cytoplasm, pleomorphic cells with blunt-ended or cigar-shaped nuclei, anisocytosis, anisokaryosis and karyomegaly. Immunohistochemically, strong positive expression for ??-SMA, vimentin, Ki67 and slight positive for desmin were found, while immulolabeling for pancytokeratin (AE1/AE3), S-100, CD31 and CD34 were negative. In conclusion, on the basis of these findings, the tumor was diagnosed as leiomyosarcoma.