The Prediction of Overall Survival With The Use of The Sarculator In Operated Soft Tissue Sarcoma of The Extremities: Monocentre Experience


Sezgin Y., Karhan O.

Eastern Journal of Medicine, vol.28, no.4, pp.804-809, 2023 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 4
  • Publication Date: 2023
  • Doi Number: 10.5505/ejm.2023.31644
  • Journal Name: Eastern Journal of Medicine
  • Journal Indexes: Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.804-809
  • Keywords: nomograms, ofttissuesarcoma, prognosis
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

Soft tissue sarcomas are rare malignancies with poor prognosis and more than 100 histologic subtypes. Due to their poor prognosis, accurate prognosis cannot be made by the staging system alone. Therefore, normograms have been developed for sarcoma patients. In this study, it was aimed to investigate the real-life data of prognosis prediction of sarculator normogram. Retrospective observational research was used in our study and the records of 146 patients were reviewed. The study included 50 patients who met the study criteria. The prognostic factors in sarcoma patients were analyzed in the study. Tumor size, tumor grade, age, and histologic subtype of the tumor were examined. In addition, all patients were graded using the sarcoma normogram and divided into percentile groups. The study's patient population had a median age of 47 years. 37 months was the median overall survival time. Patients with tumor grade 3 showed a statistically lower overall survival than those with grade 1 according to univariate analysis. Among patients divided into three groups according to Sarculator scoring, the high-risk group had a statistically significant difference of 23 months, the intermediate-risk group of 39 months, and the good-risk group of 93 months. Increased tumor size and grade were statistically significantly associated with poor survival, which was consistent with the literature. Statistically significant 5-10 year survival data were obtained in patients divided into 3 groups and compared with sarcolator. Thus, the accuracy of the Sarcolator was confirmed with real-world data.