In this study, investigation on the essential oils and ethanol extracts of naturally grown and cultivated
Satureja macrantha samples were reported. The essential oil, flavour and terpenoid-steroid-flavonoid contents of S.
macrantha samples were determined by GC-MS and their phenolic contents by LC-MS/MS. Besides, the biological
activities of the samples were investigated for their antioxidant, anti-Alzheimer, antimicrobial, cytotoxic,
antityrosinase, antiurease, antielastase and anticollagenase properties. The phenolic content and antioxidant capacity
of the cultivated sample were higher than those of the naturally grown sample. According to the GC-MS results,
terpinene-4-ol (30.9%) and p-cymene (56.7%) were determined as the major components in the essential oils of the
naturally grown and cultivated S. macrantha, respectively. The flavour analysis results showed that cis-sabinene
hydrate (20.7%) and carvacrol (42.2%) were found to be the major components in the naturally grown and cultivated
samples, respectively. While the naturally grown sample was rich in abietane diterpenoids (ferruginol (17.5 mg
analyte/g extract) and sugiol (4.2 mg analyte/g extract)), these components were not detected in the cultivated
sample. The rosmarinic acid content (0.20 and 24.87 mg analyte/g extract, respectively) of the cultivated sample
was found to be significantly higher than that of the natural sample. The biological activities of the samples were
determined to be changed in parallel with their chemical contents that are due to factors such as climatic conditions,
and soil structure.