Isoquinoline-substituted hybrid compounds: Synthesis and computational studies


Gümüş A. , Gümüş S. , Yenidede D.

20th International Electronic Conference on Synthetic Organic Chemistry, ELECTR NETWORK, 1 - 30 November 2016 identifier

  • Publication Type: Conference Paper / Full Text
  • Volume:
  • Doi Number: 10.3390/ecsoc-20-a036
  • Country: ELECTR NETWORK

Abstract

The one-pot synthesis of novel 1,4-disubstituted 1,2,3-triazoles from isoquinoline-substituted homopropargyl alcohol backbone is described (42-88% yields). A ring closing metathesis (RCM) reaction and an intramolecular Pauson-Khand reaction (PKR) of enyne system derived from a homopropargyl alcohol backbone to afford the corresponding isoquinoline-substituted dihydropyran and cyclopentenone-pyran, respectively, are also described (54% and 78% yields). Information about the structural, electronic and physico-chemical properties of the novel compounds, obtained by density functional theory application, is also reported.