Isoquinoline-substituted hybrid compounds: Synthesis and computational studies

Gümüş A., Gümüş S., Yenidede D.

20th International Electronic Conference on Synthetic Organic Chemistry, ELECTR NETWORK, 1 - 30 Kasım 2016, (Tam Metin Bildiri) identifier

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Cilt numarası:
  • Doi Numarası: 10.3390/ecsoc-20-a036
  • Basıldığı Ülke: ELECTR NETWORK
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

The one-pot synthesis of novel 1,4-disubstituted 1,2,3-triazoles from isoquinoline-substituted homopropargyl alcohol backbone is described (42-88% yields). A ring closing metathesis (RCM) reaction and an intramolecular Pauson-Khand reaction (PKR) of enyne system derived from a homopropargyl alcohol backbone to afford the corresponding isoquinoline-substituted dihydropyran and cyclopentenone-pyran, respectively, are also described (54% and 78% yields). Information about the structural, electronic and physico-chemical properties of the novel compounds, obtained by density functional theory application, is also reported.