Akademik Veri Yönetim Sistemi
NEW STUDIES IN HEALTH SCIENCES, Asst. Prof. Bişar AMAÇ, Editör, Duvar Yayınları, İzmir, ss.44-59, 2024
Psoriasis, a chronic inflammatory skin disease, involves complex immunological and cellular processes that contribute to its pathogenesis. Mast cells, well-known mediators of allergic and inflammatory responses, are key players in regulating the complex inflammatory milieu observed in psoriatic lesions. Mast cells contribute to adaptive immune processes directly through antigen presentation or indirectly by augmenting lymph nodes. Moreover, their ability to activate immune cells in psoriatic skin lesions adds depth to our understanding of the immunopathogenesis of the disease. Evidence suggests that mast cell responses in psoriasis are influenced not only by the severity of inflammation encountered, but also by the type of immune cells involved. In particular, the number of activated mast cells is significantly higher in psoriatic lesions compared to non-lesional psoriatic skin and healthy individuals, emphasising their role in disease progression. This chapter aims to elucidate the active role of mast cells in directing the pathogenesis of psoriasis through chronic inflammation. Understanding the diverse features of mast cell biology in the pathogenesis of psoriasis holds promise for the development of novel therapeutic strategies. Targeting mast cell activation pathways may offer alternative ways to reduce chronic inflammation and effectively modulate psoriatic processes. Future research efforts focused on the functional consequences of immune cell and mast cell interactions are crucial to resolve the intricacies of psoriasis pathogenesis and advance targeted therapeutic approaches.
Keywords: Psoriasis, Mast Cells, Chronic Inflammation, Pathogenesis,
Adaptive Immune Response