The Association of Hepatic Steatosis with Coronary Artery Calcification
Van Medical Journal, cilt.33, sa.4, ss.496-502, 2026 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 33 Sayı: 4
- Basım Tarihi: 2026
- Doi Numarası: 10.5505/vmj.2026.59455
- Dergi Adı: Van Medical Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.496-502
- Anahtar Kelimeler: computed tomography, coronary vessels, densitometry, Fatty liver, vascular calcification
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Van Yüzüncü Yıl Üniversitesi Adresli: Evet
Özet
Introduction: We aimed to examine the association of hepatic steatosis, age, and gender with coronary artery calcification using Computed Tomography. Materials and Methods: Patients who underwent a Coronary Computed Tomography Angiography examination over a 3-year period in a tertiary center were included. The coronary artery calcification (CAC) score, hepatic attenuation and the Liver/Spleen (L/S) Hounsfield Unit (HU) were calculated for each patient. Patients with (CAC>0) were divided into three subgroups as CAC 1-99, CAC 100-399 and CAC ≥400. The groups were compared regarding hepatic attenuation and L/S HU ratio means of statistical analysis. Results: Of the 794 patients included, 325 (41%) had a CAC score >0 and 469 (59%) had a CAC score=0. Of the 325 patients with CAC score > 0, 218 (67.1%) had scores of 1–99, 71 (21.8%) had scores of 100–399 and 36 (11.1%) had scores of ≥400. The mean liver HU was significantly higher in patients with a CAC=0 (58.3 ± 7.3), than in those with CAC>0 (55.6 ± 8.7) (p<0.001). Also, the L/S ratio was significantly higher in the CAC=0 (1.53 ± 0.43) than in the CAC >0 (1.48 ± 0.43) patients (p= 0.029). Significant inverse associations were detected between the CAC score and the liver attenuation (p < 0.001) and between the CAC score and the L/S ratio (p = 0.019). The association between age and mean liver attenuation (p=0.877) and between male gender and mean liver attenuation (p=0.287) w ere not significant. Liver attenuation demonstrated a modest discrimination ability for predicting CAC presence with an area under th e curve of 0.58. Conclusion: Older patients with hepatic steatosis may benefit from further evaluation regarding coronary art ery calcifications.