Effect of endoscopic sinus surgery on plasma asymmetric dimethylarginine levels in patients with extensive nasal polyposis

Fidan V., Alp H. H., Karaca F., Ozcan A., Ozcan K.

Journal of International Medical Research, cilt.40, sa.2, ss.565-571, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 2
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1177/147323001204000218
  • Dergi Adı: Journal of International Medical Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.565-571
  • Anahtar Kelimeler: Asymmetric dimethylarginine, Cardiovascular system, Endoscopic sinus surgery, Nasal polyposis, Pulmonary arterial pressure
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

This study examined the effect of endoscopic sinus surgery (ESS) on plasma levels of asymmetric dimethylarginine (ADMA) and mean pulmonary arterial pressure (mPAP) in patients with extensive nasal polyposis (ENP). METHODS: Preoperative and 3-month post-ESS plasma levels of ADMA and mPAP were measured in patients with ENP and in age-and gender-matched controls. RESULTS: The study included 45 patients with ENP and 31 controls (mean ± SD age 39.4 ± 8.8 and 38.1 ± 9.6 years, respectively). The mean preoperative ADMA level in ENP patients (0.69 ± 0.27 μmol/l) was statistically significantly lower than in the control group (1.08 ± 0.37 μmol/l). The postoperative ADMA level increased significantly in ENP patients (0.97 ± 0.36 μmol/l) versus the preoperative level. Mean preoperative mPAP in ENP patients (25.7 ± 5.4 mmHg) was statistically significantly higher than in the control group (20.8 ± 2.1 mmHg), and ENP patients showed significant decreases in mPAP after (21.9 ± 3.5 mmHg) versus before ESS. CONCLUSION: Patients with ENP had lower plasma ADMA levels compared with healthy controls, however ADMA levels and mPAP improved in ENP patients after ESS. © 2012 Field House Publishing LLP.