TURKISH JOURNAL OF MEDICAL SCIENCES, vol.45, no.6, pp.1380-1389, 2015 (SCI-Expanded)
Background/aim: Treating animals repeatedly with intermittent and increasing morphine doses has been suggested to allow some withdrawal during each dosing interval, which causes repeated stress. The present study aimed to test this hypothesis and assess sex-related differences in withdrawal signs and their suppression by clonidine.