Spontaneous withdrawal in intermittent morphine administration in rats and mice: effect of clonidine coadministration and sex-related differences


Allahverdiyev O., Zengin Turkmen A., Nurten A., Sehirli I., Enginar N.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.45, ss.1380-1389, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 45 Konu: 6
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3906/sag-1408-137
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Sayfa Sayıları: ss.1380-1389

Özet

Background/aim: Treating animals repeatedly with intermittent and increasing morphine doses has been suggested to allow some withdrawal during each dosing interval, which causes repeated stress. The present study aimed to test this hypothesis and assess sex-related differences in withdrawal signs and their suppression by clonidine.