Spontaneous withdrawal in intermittent morphine administration in rats and mice: effect of clonidine coadministration and sex-related differences


Allahverdiyev O., Zengin Turkmen A., Nurten A., Sehirli I., Enginar N.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.45, no.6, pp.1380-1389, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 6
  • Publication Date: 2015
  • Doi Number: 10.3906/sag-1408-137
  • Title of Journal : TURKISH JOURNAL OF MEDICAL SCIENCES
  • Page Numbers: pp.1380-1389

Abstract

Background/aim: Treating animals repeatedly with intermittent and increasing morphine doses has been suggested to allow some withdrawal during each dosing interval, which causes repeated stress. The present study aimed to test this hypothesis and assess sex-related differences in withdrawal signs and their suppression by clonidine.