Akademik Veri Yönetim Sistemi
Microchemical Journal, cilt.222, 2026 (SCI-Expanded, Scopus)
Donepezil is an FDA-approved Alzheimer's and dementia medication. Donepezil hydrochloride can cause gastrointestinal side effects such as diarrhea, stomach bleeding, muscle convulsions, insomnia, nausea and vomiting. Therefore, it is very important to develop reliable, sensitive, economical, pre-treatment and expert-free, short analysis time and simple-to-use methods such as potentiometry for the determination of donepezil. The selection of ionophore is crucial in potentiometric sensors. Ionophores are a crucial membrane component that greatly influences the selectivity of the sensor. In this study, a sensor was developed for the determination of donepezil and MIL-53(Al) was used as the ionophore. The sensor showed a slope value of 51.3 (R2 = 0.9967), wide linear working range (1.0 × 10−2-1.0 × 10−9 M), high selectivity, low detection limit (8.0 × 10−10 M), wide pH working range (2.16–8.02), short response time (10 s), high repeatability and reproducibility. The donepezil-selective sensor showed very high selectivity towards donepezil even in the presence of commonly found ions (Ca2+, K+, Na+ etc.). Stability studies were conducted for the Donepezil selective sensor (potential drift and water layer test) and very successful results were obtained. Additionally, in order to evaluate the potentiometry method used in this study in terms of environmental sustainability, AGREE (Analytical GREEnness Assessor), MoGAPI (Modified Green Analytical Procedure Index) and BAGI (Post-Analytical GREEnness Index) tools were used to evaluate it in terms of greenness. A score of 0.68 was obtained for AGREE, 82 for MoGAPI and 77.5 for BAGI.