Catalase Activity, Serum Trace Element and Heavy Metal Concentrations, and Vitamin A, D and E Levels in Pre-eclampsia

Kolusari A., KURDOGLU M., Yildizhan R., ADALI E., EDIRNE T., CEBI A., ...More

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, vol.36, no.6, pp.1335-1341, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 6
  • Publication Date: 2008
  • Doi Number: 10.1177/147323000803600622
  • Journal Name: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1335-1341
  • Keywords: PRE-ECLAMPSIA, CATALASE, TRACE ELEMENT, HEAVY METAL, VITAMIN A, VITAMIN D, VITAMIN E, ENDOTHELIAL DYSFUNCTION, PLASMA-CONCENTRATIONS, OXIDATIVE STRESS, WOMEN, PREGNANCY, LEAD, ZINC, IRON, EXPOSURE, DAMAGE
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

Catalase (antioxidant enzyme) activity in erythrocytes and serum levels of trace elements (copper, iron, zinc), heavy metals (cadmium, cobalt) and vitamins A (retinol), D (cholecalciferol) and E (alpha-tocopherol) were measured in 145 subjects comprising 47 pre-eclamptic pregnant women (PE), 48 healthy pregnant women (HP) and 50 healthy non-pregnant controls (NP). Catalase, vitamins A, D and E and levels of cobalt were significantly lower in the PE group compared with the HP and NP groups, whereas levels of copper, iron and cadmium were significantly higher in the PE group than in the HP and NP groups. Levels of zinc were significantly lower in both the PE and HP groups compared with the NP group. This assessment of oxidant/antioxidant imbalance in pregnant women could be useful in the early identification of pre-eclampsia and antioxidant supplementation in the early weeks of gestation might be useful.