Background. Lake Van, the second-largest soda lake in the world, has a pH 9.8 value. A fish, locally known as Van fish, Alburnus tarichi (Guldenstadt, 1814), is an endemic fish of Lake Van and known also as pearl mullet, tarek, or Van bleak. Tebuconazole is a widely used pesticide around Lake Van. In this study, we will focus on the effects of tebuconazole on Van fish blood to provide critical information on the environmental risk assessment of pesticides in various aquatic environments.