Defibrotide activity in experimental frostbite injury


Ozyazgan I., Tercan M., Bekerecioglu M., Melli M., Ustun H., Gunay G.

BRITISH JOURNAL OF PLASTIC SURGERY, vol.51, no.6, pp.450-454, 1998 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 6
  • Publication Date: 1998
  • Doi Number: 10.1054/bjps.1997.0061
  • Journal Name: BRITISH JOURNAL OF PLASTIC SURGERY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.450-454

Abstract

The pathogenesis of frostbite injury has not been completely elucidated although the available evidence suggests it is an inflammatory reaction following reperfusion injury. Defibrotide given i.p, at 40 mg/kg/ day for three days to rabbits, the ears of which were subjected to frostbite, decreased the presence of inflammatory cells (mast cells -76%; neutrophils -40.4%) and increased prostaglandin I-2 (PGI(2)) (as 6-Keto-PGF(1 alpha)) in the involved skin. Thromboxane A(2) (TxA(2)) (as TxB(2)) was unaffected. These data strengthen the view that an inflammatory process is the underlying cause of frostbite injury and that Defibrotide is active in pathological situations involving an inflammatory process like in frostbite.