Defibrotide activity in experimental frostbite injury


Ozyazgan I., Tercan M., Bekerecioglu M., Melli M., Ustun H., Gunay G.

BRITISH JOURNAL OF PLASTIC SURGERY, cilt.51, ss.450-454, 1998 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 51 Konu: 6
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1054/bjps.1997.0061
  • Dergi Adı: BRITISH JOURNAL OF PLASTIC SURGERY
  • Sayfa Sayısı: ss.450-454

Özet

The pathogenesis of frostbite injury has not been completely elucidated although the available evidence suggests it is an inflammatory reaction following reperfusion injury. Defibrotide given i.p, at 40 mg/kg/ day for three days to rabbits, the ears of which were subjected to frostbite, decreased the presence of inflammatory cells (mast cells -76%; neutrophils -40.4%) and increased prostaglandin I-2 (PGI(2)) (as 6-Keto-PGF(1 alpha)) in the involved skin. Thromboxane A(2) (TxA(2)) (as TxB(2)) was unaffected. These data strengthen the view that an inflammatory process is the underlying cause of frostbite injury and that Defibrotide is active in pathological situations involving an inflammatory process like in frostbite.