Antinociceptive and anti-inflammatory activities of Ballota inaequidens

Yilmaz B. S., Ozbek H., Citoglu G. S.

PHARMACEUTICAL BIOLOGY, vol.44, no.8, pp.636-641, 2006 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 8
  • Publication Date: 2006
  • Doi Number: 10.1080/13880200600897577
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.636-641
  • Van Yüzüncü Yıl University Affiliated: No


The water extract of Ballota inaequidens Hub.-Mor. & Patzak (Lamiaceae) was investigated for antinociceptive and anti-inflammatory activities in mice and rats. The tail-flick test, acetic acid-induced writhing test, and the carrageenan-induced rat paw edema test were used to determine these effects. Our findings show that Ballota inaequidens caused dose-related inhibition in the acetic acid-induced abdominal stretching in mice. The medium effective dose (ED50) value of Ballota inaequidens was found to be 85.38 mg/kg. Ballota inaequidens showed no significant changes in the nociceptive threshold of the tail-flick test but did show an inhibition of paw edema induced by carrageenan. The ED50 value of Ballota inaequidens was found to be 99.42 mg/kg. The current study reveals that the water extract of Ballota inaequidens possesses promising antinociceptive and anti-inflammatory activities.